If you’ve started using retinol for firmer skin, less visible pores, and a more even-looking complexion, you’ve chosen one of the most researched actives in skincare. However, retinol comes with certain rules—especially when you add new products to your routine. Beyond the results, the way you combine products matters a lot, because some ingredients don’t work well with retinol and can cause irritation, dryness, or discomfort. Below are six combinations to avoid—and what to use instead.
Why you should be careful with retinol combos
Retinol is derived from vitamin A and is frequently used to reduce wrinkles, improve skin texture, and control acne. This ingredient speeds up cell turnover and stimulates collagen production. However, it can make skin more sensitive than usual, which means it becomes more easily irritated by other actives.
1. Exfoliating acids AHA/BHA (glycolic, lactic, salicylic acid)
Applying retinol at the same time as exfoliating acids increases the risk of flaking and irritation. For example, glycolic acid has an intense exfoliating effect, and combined with retinol can lead to dryness or red patches on the skin. Recommendation: alternate applications (acids one day, retinol the next).
2. Vitamin C
Vitamin C serums, like C-Glow from skinseen.ro, provide brightness and antioxidant protection. However, when applied together with retinol, they can reduce each other’s effectiveness and increase skin sensitivity. Recommendation: vitamin C in the morning, retinol at night.
3. Niacinamide
Niacinamide reduces redness and evens out the skin. It can sometimes be paired with retinol, but people with sensitive skin may experience stinging. Recommendation: niacinamide in the morning, retinol at night.
4. Benzoyl peroxide
Combining benzoyl peroxide with retinol can cause severe dryness and irritation. Recommendation: peroxide in the morning, retinol at night. See also the complete acne guide.
5. Azelaic acid
Azelaic acid reduces inflammation and hyperpigmentation, but when paired with retinol it can irritate the skin. Recommendation: azelaic acid in the morning, retinol at night.
6. Other harsh ingredients and procedures
Avoid using multiple retinoids at once and applying retinol immediately after aggressive procedures (laser, microdermabrasion). Also, denatured alcohol and strong fragrances can further sensitize the skin.
How to introduce retinol correctly into your routine
Start with 2–3 applications per week, at night, on clean, dry skin. After 20–30 minutes, apply a moisturizer with ceramides, hyaluronic acid, or centella asiatica. Don’t forget daily SPF 30+ sun protection. You can also try a dedicated serum such as Rejuvenate Serum.
This text is for informational purposes and does not replace a dermatology consultation. For major changes to your skincare routine, consult a specialist.