Tranexamic acid is an increasingly common ingredient in medical and cosmetic products, appreciated for its beneficial effects on blood clotting, but also for its effectiveness in treating pigment spots and skin redness. Although initially used strictly for medical purposes, today tranexamic acid is a substance that is also intensively studied in the field of dermatology and skin care.
Discovered in the 1960s by Japanese scientists, tranexamic acid has been used for decades to reduce excessive bleeding in surgery and various conditions that can cause bleeding. However, in recent years, clinical studies and dermatological observations have highlighted new uses for tranexamic acid, especially for combating hyperpigmentation and evening skin tone.
In the following lines, you will discover, step by step, how tranexamic acid works, what real benefits it can bring to your skin, where it finds its place in medical treatments, and how you can confidently integrate it into your own skincare routine — for a brighter, more even, and healthier complexion.
What is tranexamic acid and how does it work in the body?
Tranexamic acid is a synthetic form of a naturally occurring amino acid called lysine. In medicine, it has been used for many years to help the body stop excessive bleeding. How does it do this? In short, it prevents the breakdown of blood clots that help stop bleeding.
When it comes to skin, things work a little differently, but the principle is just as interesting. Tranexamic acid acts on skin cells (called keratinocytes) and reduces those processes that lead to inflammation and the excess production of melanin — the pigment responsible for brown spots or uneven skin tone.
In other words, tranexamic acid helps the skin calm down and naturally regulate its pigment production. The result? Over time, pigment spots visibly fade, and the complexion takes on a more even, brighter, and healthier appearance.
Proven benefits of tranexamic acid:
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Reduction of melasma and age spots
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Evens out skin tone
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Decreased skin inflammation
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Preventing the appearance of post-inflammatory hyperpigmentation (PIH)
Medical uses of tranexamic acid
Initially, tranexamic acid was approved for medical use in various settings where bleeding control was essential.
Common medical indications:
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Major surgery (cardiac, gynecological, orthopedic)
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Post-traumatic bleeding
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Menorrhagia (heavy menstruation)
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Hereditary bleeding disorders (such as von Willebrand disease)
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Dentistry: preventing bleeding after tooth extractions
For example, in the case of major surgeries, intravenous administration of tranexamic acid can reduce blood loss by up to 30-50%, according to a study published in The Lancet in 2021.
Forms of medical administration:
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Oral tablets
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Intravenous injections
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Local solutions (e.g. in dentistry)
The role of tranexamic acid in dermatology and aesthetics
Although tranexamic acid has a long history in classical medicine, in recent years attention has increasingly shifted to its benefits for skin care. If so far we have talked about its medical role, from now on we will focus on what makes it truly special in the field of cosmetics. In dermatology, tranexamic acid is successfully used to combat:
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melasma
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Post-inflammatory spots
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Skin redness and sensitivity
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Sun-induced hyperpigmentation
A study published in the Journal of the American Academy of Dermatology demonstrated that topical use of tranexamic acid at a concentration of 5% for 12 weeks resulted in a 50-60% reduction in pigmentation in melasma, compared to placebo.
Dermatological mechanism:
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Inhibition of the release of growth factors responsible for melanogenesis
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Reducing skin inflammation
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Decreased vascular permeability (which helps reduce redness)
Cosmetic forms of tranexamic acid
On the market, tranexamic acid is included in multiple cosmetic products. It is preferred for its visible, yet gentle effects on the skin.
Examples of cosmetic products:
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Serums with tranexamic acid 2%-5%
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Depigmenting creams
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Treatment masks
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Combinations with other active ingredients: niacinamide, vitamin C, retinol
Advantages of tranexamic acid:
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Suitable for all skin types, including sensitive skin
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Very good tolerability
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Can be used safely long-term
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Compatible with other ingredients (except strong exfoliating acids, where caution is needed)
For visible and safe results, it is essential to choose correctly formulated products, with effective concentrations and complementary ingredients. For example, the Skinseen range includes:
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NIACINAMIDE 10% + TXA 4% SERUM — ideal serum for reducing age spots and evening out skin tone
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REJURECIPE TXA CREAM — cream for an antioxidant and corrective effect
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RETINOL EYE WRINKLE - eye serum enhanced with tranexamic acid and peptides for a complete anti-aging effect, providing a smooth, bright and revitalized appearance to tired eyes.
Skinseen products are formulated to be gentle yet effective, also suitable for people with sensitive skin or prone to redness.
What ingredients does tranexamic acid combine well with and what effects can you achieve?
One of the great advantages of tranexamic acid is that it fits very well into a complex care routine, being a gentle and easy-to-adapt ingredient. When combined correctly with other active ingredients, it can enhance its effects and bring visible and faster results.
Here are some ideal combinations:
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Tranexamic acid + niacinamide
This combination is one of the most popular. Niacinamide soothes the skin, reduces inflammation, and also helps even out skin tone. Together, the two ingredients work synergistically to fade age spots and strengthen the skin barrier. -
Tranexamic acid + vitamin C
Vitamin C is a powerful antioxidant that helps brighten skin and protect against oxidative stress. Along with tranexamic acid, it can speed up the fading process of blemishes and give skin a brighter, more even appearance. -
Tranexamic acid + hyaluronic acid
For an intense moisturizing effect, this combination is ideal. Hyaluronic acid ensures optimal skin hydration, while tranexamic acid works on pigmentation without sensitizing the skin. -
Tranexamic acid + retinoids (with caution)
Retinoids (such as retinol) accelerate cell turnover. Combined with tranexamic acid, they can give excellent results in cases of melasma and persistent hyperpigmentation. However, this combination should be done gradually and under the supervision of a dermatologist, especially if you have sensitive skin.
Therefore, depending on your skin's needs, tranexamic acid can be easily integrated with other key ingredients for a personalized and effective routine. It's just important to maintain a consistent application and don't forget daily sun protection, which is essential in any hyperpigmentation treatment.
How to integrate tranexamic acid into your skin care routine
If you want to add tranexamic acid to your routine, here are some recommendations:
Practical steps:
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Gentle cleansing — a non-irritating cleansing gel or foam
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Tranexamic acid serum — apply morning or evening, on clean skin
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Hydration — with a cream adapted to your skin type
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Sun protection — SPF 30-50, daily (essential for optimal results)
Useful tips:
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For sensitive skin, start with a low concentration (2-3%)
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Avoid combining in the same routine with strong AHA/BHA to prevent irritation
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Visible results generally appear after 4-8 weeks of consistent use
Tranexamic Acid - Side Effects and Contraindications
Although tranexamic acid is well tolerated, there are some possible adverse effects, especially when administered orally or by injection.
Possible side effects:
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Nausea, stomach discomfort (for oral form)
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DISORDERS
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Mild local irritation (for topical application)
Contraindications:
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People at high risk of thrombosis
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History of stroke
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Pregnancy and breastfeeding (caution and medical consultation are recommended)
Cosmetic use - side effects
For the cosmetic use of tranexamic acid, the risks are much lower, but it is important to choose quality products and gradually introduce them into your routine.
Conclusion
Tranexamic acid is now recognized as a valuable ingredient in both traditional medicine and dermatology and cosmetology. Its ability to reduce hyperpigmentation, soothe inflammation, and even out skin tone makes it an excellent option for people looking to treat age spots or melasma.
Used correctly and in combination with other beneficial ingredients, tranexamic acid can bring visible and lasting improvements to the appearance of the skin. In addition, its safety profile is excellent, both for topical administration and, in certain situations, for controlled medical use.
If you are interested in effective solutions against hyperpigmentation, tranexamic acid is definitely worth considering — either in the form of dermato-cosmetic products or as part of a personalized dermatological treatment.
With patience, discipline, and choosing the right products, tranexamic acid can become your trusted ally in your skin care routine.
(FAQ)
What is tranexamic acid and what is it used for?
Tranexamic acid is a synthetic derivative of the amino acid lysine, with antifibrinolytic properties. It was originally used in medicine to reduce excessive bleeding. It is now also highly valued in dermatology for treating pigment spots, melasma and evening skin tone.
How does tranexamic acid work on pigment spots?
Tranexamic acid inhibits the release of factors that stimulate melanin production and reduces local inflammation. Thus, it prevents the formation of pigment spots and helps to fade existing ones, especially in cases of melasma and post-inflammatory hyperpigmentation.
How quickly do results appear using tranexamic acid on the skin?
The first visible results usually appear after 4-8 weeks of consistent use. However, for significant improvements in cases of melasma or deep pigment spots, a minimum of 3 months of treatment is required.
Is tranexamic acid suitable for all skin types?
Yes, tranexamic acid is well tolerated by most skin types, including sensitive or rosacea-prone skin. Due to its gentle mechanism, it is an effective alternative to more aggressive exfoliating acids.
What concentration of tranexamic acid is effective in cosmetic products?
The most common effective concentrations in dermato-cosmetic products are between 2% and 5%. Studies have shown that these concentrations are sufficient to reduce pigmentation without causing significant irritation.
Can tranexamic acid be combined with other active ingredients?
Yes, tranexamic acid combines well with ingredients like niacinamide, vitamin C, hyaluronic acid, or retinol (with caution). It is recommended to avoid co-application with strong AHA/BHA or concentrated retinoids to prevent skin sensitization.
Is tranexamic acid safe during pregnancy?
Topical (local) use of tranexamic acid is considered relatively safe, but it is always recommended to consult your doctor or dermatologist before introducing new products into your skincare routine during pregnancy or breastfeeding.
Does tranexamic acid have side effects?
When administered topically, tranexamic acid is well tolerated. It may rarely cause mild irritation or redness, especially at the beginning of use. Oral or injectable administration is reserved strictly for medical indications and requires careful monitoring.